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Bone mineral density in patients with multiple sclerosis, hereditary ataxia or hereditary spastic paraplegia after at least 10 years of disease - a case control study.
- Source :
-
BMC neurology [BMC Neurol] 2016 Dec 05; Vol. 16 (1), pp. 252. Date of Electronic Publication: 2016 Dec 05. - Publication Year :
- 2016
-
Abstract
- Background: Although disability is considered the main cause of low bone mineral density (BMD) in multiple sclerosis (MS), other factors related to the disease process or treatment could also be involved. The aim of this study was to assess whether patients with MS are more likely to develop low BMD (osteopenia or osteoporosis) than patients with the non-inflammatory neurological diseases Hereditary Spastic Paraplegia (HSP) and Hereditary Ataxia (HA).<br />Methods: We performed a case control study comparing BMD (spine, hip and total body) and biochemical measures of bone metabolism in 91 MS patients and 77 patients with HSP or HA, matched for age, gender and disability. Both patient groups had lived with the disease for at least 10 years.<br />Results: In total 74.7% of the patients with MS and 75.3% of the patients with HSP or HA had osteopenia (-2.5 < T- score < -1.0) or osteoporosis (T- score ≤ -2.5) in one or more sites. Osteoporosis was more common in patients with MS than with HSP/HA (44.0 vs 20.8%, p =0.001). This difference was not significant after correction for confounders (p = 0.07), nor were any of the biochemical markers.<br />Conclusion: Most patients with disabling neurological diseases like MS and HSP/HA develop osteopenia or osteoporosis. MS patients had osteoporosis more frequently than HA/HSP patients, though the difference was not significant after adjusting for confounders. Osteoporosis and bone health should be considered in all patients with both inflammatory and degenerative chronic neurological diseases.
- Subjects :
- Adult
Bone Diseases, Metabolic diagnostic imaging
Bone Diseases, Metabolic metabolism
Case-Control Studies
Female
Humans
Male
Middle Aged
Osteoporosis diagnostic imaging
Osteoporosis etiology
Osteoporosis metabolism
Bone Density physiology
Bone Diseases, Metabolic etiology
Disease Progression
Multiple Sclerosis complications
Spastic Paraplegia, Hereditary complications
Spinocerebellar Degenerations complications
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2377
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC neurology
- Publication Type :
- Academic Journal
- Accession number :
- 27919248
- Full Text :
- https://doi.org/10.1186/s12883-016-0771-4