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ERG expression in multiple myeloma-A potential diagnostic pitfall.
- Source :
-
Pathology, research and practice [Pathol Res Pract] 2017 Feb; Vol. 213 (2), pp. 130-132. Date of Electronic Publication: 2016 Nov 03. - Publication Year :
- 2017
-
Abstract
- Introduction: ERG expression has been described as a frequent event in prostate cancer indicating poor prognosis and promoting oncogenesis. It has also been demonstrated in Ewing's sarcoma, acute myeloid leukemia and acute T-lymphoblastic leukemia but could not be found in other epithelial tumors, Hodgkin's or Non-Hodgkin's lymphoma. We aimed to analyze ERG expression in multiple myeloma, following an index case of a patient with metastases of unknown origin in the spine strongly expressing ERG, which were thought to be of prostatic origin but turned out to be plasmacytic lesions.<br />Material and Methods: We subsequently selected 12 formalin-fixed, paraffin-embedded tissue samples of multiple myeloma from our archives and performed immunohistochemical staining for ERG.<br />Results: All 12 analyzed cases showed strong nuclear expression of ERG in >90% of tumor cells (myeloma cells).<br />Conclusions: This report highlights a potential and critical diagnostic pitfall in biopsy specimens where morphology is only of limited assistance in reaching the correct diagnosis. It urges pathologists to exercise caution in cases where strong ERG-positivity implicates the presence of a prostatic neoplasia and illustrates the need for further immunohistochemical examination.<br /> (Copyright © 2016 Elsevier GmbH. All rights reserved.)
- Subjects :
- Aged
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Multiple Myeloma metabolism
Multiple Myeloma pathology
Plasmacytoma metabolism
Plasmacytoma pathology
Prostatic Neoplasms metabolism
Prostatic Neoplasms pathology
Spinal Neoplasms metabolism
Spinal Neoplasms surgery
Thoracic Vertebrae
Transcriptional Regulator ERG metabolism
Biomarkers, Tumor metabolism
Multiple Myeloma diagnosis
Plasmacytoma diagnosis
Prostatic Neoplasms diagnosis
Spinal Neoplasms secondary
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 213
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 27913051
- Full Text :
- https://doi.org/10.1016/j.prp.2016.10.014