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Bone Area Provides a Responsive Outcome Measure for Bone Changes in Short-term Knee Osteoarthritis Studies.
- Source :
-
The Journal of rheumatology [J Rheumatol] 2016 Dec; Vol. 43 (12), pp. 2179-2182. Date of Electronic Publication: 2016 Oct 01. - Publication Year :
- 2016
-
Abstract
- Objective: To analyze the 3-D bone area from an osteoarthritis (OA) cohort demonstrating no change in cartilage thickness.<br />Methods: Twenty-seven women with painful medial knee OA had magnetic resonance images at 0, 3, and 6 months. Images were analyzed using active appearance models.<br />Results: At 3 and 6 months, the mean change in medial femoral bone area was 0.34% (95% CI 0.04-0.64) and 0.61% (95% CI 0.32-0.90), respectively. Forty-one percent of the subjects had progression greater than the smallest detectable difference at 6 months.<br />Conclusion: In this small cohort at high risk of OA progression, bone area changed at 3 and 6 months when cartilage morphometric measures did not.
Details
- Language :
- English
- ISSN :
- 0315-162X
- Volume :
- 43
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 27909144
- Full Text :
- https://doi.org/10.3899/jrheum.151118