Back to Search
Start Over
Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review.
- Source :
-
Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2017 Oct; Vol. 36 (5), pp. 1215-1230. Date of Electronic Publication: 2016 Nov 19. - Publication Year :
- 2017
-
Abstract
- Aims: Hyperhomocysteinemia (HHcy) is known to increase the risk of many diseases. Factors influencing HHcy in healthy and hypertensive subjects remain under-researched.<br />Methods: A large population-based study was conducted in 60 communities from Shenzhen, China. Responses to standardized questions on lifestyle factors and blood samples were collected from all participants after a 12-h overnight fast. Multiple linear and multivariate logistic regressions were used to explore risk factors for HHcy. Results were then compared to those from a systematic review of English-language articles listed in Pubmed, EBSCOhost, Web of Science, Embase and Cochrane libraries that investigated HHcy risk factors in healthy and hypertensive subjects.<br />Results: A total of 1586 healthy (Male/Female = 642/944) and 5935 hypertensive subjects (Male/Female = 2928/3007) participated in our population-based study. In logistic regression analyses, age, BMI and creatinine (Cr) were risk factors, while being female, fruit intake and physical activity were protective factors for HHcy in healthy subjects. In hypertensive subjects, seven [age, smoking, salt intake, systolic blood pressure (SBP), uric acid, triglycerides (TG), and Cr] and four [female, fruit intake, total cholesterol (TC), and glucose] factors were associated with higher and lower HHcy respectively. The review of 71 studies revealed that potential risk factors for Hcy included nutritional, physiologic, lifestyle habits, ethnicity, genetics, interactions between gene-environment, gene-gene, gene-nutritional, environment-environment, nutritional-nutritional.<br />Conclusion: Our study indicates the potential importance of increasing folic acid and vitamin B supplementation, daily fruit and vegetable intake, regular exercise and refraining from tobacco smoking and alcohol consumption as preventive strategies for Hcy.<br /> (Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
- Subjects :
- Blood Pressure
Body Mass Index
China
Creatinine blood
Diet, Healthy
Dietary Supplements
Exercise
Female
Folic Acid administration & dosage
Folic Acid blood
Fruit
Homocysteine blood
Humans
Hyperhomocysteinemia blood
Hypertension blood
Life Style
Male
Risk Factors
Triglycerides blood
Uric Acid blood
Vegetables
Vitamin B Complex administration & dosage
Vitamin B Complex blood
Hyperhomocysteinemia diagnosis
Hyperhomocysteinemia epidemiology
Hypertension epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1983
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical nutrition (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 27908565
- Full Text :
- https://doi.org/10.1016/j.clnu.2016.11.011