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An additional breakpoint region in the BCL-1 locus associated with the t(11;14)(q13;q32) translocation of B-lymphocytic malignancy.
- Source :
-
Blood [Blood] 1989 Oct; Vol. 74 (5), pp. 1801-6. - Publication Year :
- 1989
-
Abstract
- The t(11;14)(q13;q32) translocation is associated with human B-lymphocytic malignancy. This translocation divides the IgH locus on chromosome 14q32 and may activate a postulated proto-oncogene, bcl-1, located on chromosome 11q13. Two samples of chronic lymphocytic leukemia with the t(11;14)(q32;q13) translocation were studied. The break in one sample was shown to join Jh sequences with the previously described bcl-1 major translocation cluster. DNA blots of the second sample suggested that Jh sequences were joined to a different breakpoint region on chromosome 11. This translocation was cloned and found to link the human Jh3 region and a new breakpoint region 63 kb telomeric of the major translocation cluster. This translocation occurred in part as the result of an aberrant D-J recombination. Recurrent translocations human B-lymphocytic malignancy. The definition of a new breakpoint region may aid the identification of the postulated bcl-1 gene.
- Subjects :
- Base Sequence
Cell Line
DNA, Neoplasm genetics
Genomic Library
Humans
Leukemia, Lymphocytic, Chronic, B-Cell immunology
Molecular Sequence Data
Proto-Oncogene Mas
Restriction Mapping
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 14
Genes, Immunoglobulin
Leukemia, Lymphocytic, Chronic, B-Cell genetics
Receptors, Antigen, B-Cell genetics
Translocation, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0006-4971
- Volume :
- 74
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 2790203