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High-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis.
- Source :
-
Postgraduate medical journal [Postgrad Med J] 2017 Apr; Vol. 93 (1098), pp. 215-220. Date of Electronic Publication: 2016 Nov 29. - Publication Year :
- 2017
-
Abstract
- Periodontal disease (PD) is generated by microorganisms. These microbes can enter the general circulation causing a bacteraemia. The result can be adverse systemic effects, which could promote conditions such as cardiovascular disease. Level A evidence supports that PD is independently associated with arterial disease. PD is a common chronic condition affecting the majority of Americans 30 years of age and older. Atherosclerosis remains the largest cause of death and disability. Studies indicate that the adverse cardiovascular effects from PD are due to a few putative or high-risk bacteria: Aggregatibacter actinomycetemcomitans , Porphyromonas gingivalis , Tannerella forsythia , Treponema denticola or Fusobacterium nucleatum There are three accepted essential elements in the pathogenesis of atherosclerosis: lipoprotein serum concentration, endothelial permeability and binding of lipoproteins in the arterial intima. There is scientific evidence that PD caused by the high-risk pathogens can influence the pathogenesis triad in an adverse manner. With this appreciation, it is reasonable to state PD, due to high-risk pathogens, is a contributory cause of atherosclerosis. Distinguishing this type of PD as causal provides a significant opportunity to reduce arterial disease.<br /> (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)
- Subjects :
- Aggressive Periodontitis microbiology
Aggressive Periodontitis physiopathology
Bacterial Load
Coronary Artery Disease microbiology
Coronary Artery Disease physiopathology
Humans
Risk Factors
United States
Aggregatibacter actinomycetemcomitans pathogenicity
Aggressive Periodontitis complications
Coronary Artery Disease etiology
Porphyromonas gingivalis pathogenicity
Treponema denticola pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 1469-0756
- Volume :
- 93
- Issue :
- 1098
- Database :
- MEDLINE
- Journal :
- Postgraduate medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 27899684
- Full Text :
- https://doi.org/10.1136/postgradmedj-2016-134279