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Humoral and cellular response after varicella vaccination in VZV IgG seronegative kidney transplant candidates.
- Source :
-
Vaccine [Vaccine] 2017 Jan 03; Vol. 35 (1), pp. 71-76. Date of Electronic Publication: 2016 Nov 26. - Publication Year :
- 2017
-
Abstract
- Background: In immunocompromised patients, primary infection with VZV may have a disastrous clinical course. Vaccination of VZV-seronegative patients on the waiting list for renal transplantation may prevent severe disease. However, the immunologic response of end-stage renal disease patients to peptide vaccines is far from optimal. Our question was whether end-stage renal disease patients with undetectable VZV-IgG levels were able to mount an adequate humoral and cellular response to a live attenuated varicella vaccine.<br />Methods: Kidney transplant candidates with undetectable VZV levels were vaccinated twice with a live attenuated varicella vaccine at an interval of 6weeks. VZV IgG levels were analysed till 2years after vaccination. The VZV-specific T-cell reactivity was determined prior to vaccination and after transplantation.<br />Results: Seventy-seven percent (40/52) of the vaccinees reached positive VZV-IgG levels after vaccination (responders). Eighty-two percent (9/11) showed an increase in VZV-specific CD4 <superscript>+</superscript> memory T-cells (both central and effector memory cells). The percentage VZV-specific CD8 <superscript>+</superscript> memory T-cells did not increase. None of the non-responders suffered from primary VZV after transplantation. No severe vaccine-related adverse events were reported, only spontaneously resolving local skin irritation.<br />Conclusion: The live attenuated varicella vaccine evokes positive VZV IgG-levels and VZV-specific memory T-cells in VZV-seronegative potential kidney transplant candidates.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Antibodies, Viral blood
Female
Humans
Immunoglobulin G blood
Immunologic Memory
Male
Middle Aged
Prospective Studies
T-Lymphocytes immunology
Vaccines, Attenuated administration & dosage
Vaccines, Attenuated immunology
Young Adult
Chickenpox Vaccine administration & dosage
Chickenpox Vaccine immunology
Herpesvirus 3, Human immunology
Immunity, Cellular
Immunity, Humoral
Kidney Transplantation
Transplant Recipients
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 27899225
- Full Text :
- https://doi.org/10.1016/j.vaccine.2016.11.043