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Postexposure Prophylaxis After Possible Anthrax Exposure: Adherence and Adverse Events.
- Source :
-
Health security [Health Secur] 2016 Nov/Dec; Vol. 14 (6), pp. 419-423. Date of Electronic Publication: 2016 Nov 29. - Publication Year :
- 2016
-
Abstract
- Anthrax postexposure prophylaxis (PEP) was recommended to 42 people after a laboratory incident that involved potential aerosolization of Bacillus anthracis spores in 2 laboratories at the Centers for Disease Control and Prevention in 2014. At least 31 (74%) individuals who initiated PEP did not complete either the recommended 60 days of antimicrobial therapy or the 3-dose vaccine regimen. Among the 29 that discontinued the antimicrobial component of PEP, most (38%) individuals discontinued PEP because of their low perceived risk of infection; 9 (31%) individuals discontinued prophylaxis due to PEP-related minor adverse events, and 10% cited both low risk and adverse events as their reason for discontinuation. Most minor adverse events reported were gastrointestinal complaints, and none required medical attention. Individuals taking ciprofloxacin were twice as likely (RR = 2.02, 95% CI = 1.1-3.6) to discontinue antimicrobial prophylaxis when compared to those taking doxycycline. In the event anthrax PEP is recommended, public health messages and patient education materials will need to address potential misconceptions regarding exposure risk and provide information about possible adverse events in order to promote PEP adherence.
- Subjects :
- Adult
Anti-Bacterial Agents adverse effects
Bacillus anthracis
Centers for Disease Control and Prevention, U.S.
Ciprofloxacin administration & dosage
Ciprofloxacin adverse effects
Doxycycline administration & dosage
Doxycycline adverse effects
Female
Georgia
Humans
Male
Occupational Exposure prevention & control
United States
Anthrax prevention & control
Anti-Bacterial Agents administration & dosage
Medication Adherence psychology
Post-Exposure Prophylaxis
Vaccination Refusal psychology
Subjects
Details
- Language :
- English
- ISSN :
- 2326-5108
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Health security
- Publication Type :
- Academic Journal
- Accession number :
- 27898235
- Full Text :
- https://doi.org/10.1089/hs.2016.0060