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Polymorphisms in cytokine genes influence cognitive and functional performance in a population aged 75 years and above.
- Source :
-
International journal of geriatric psychiatry [Int J Geriatr Psychiatry] 2017 Dec; Vol. 32 (12), pp. 1401-1410. Date of Electronic Publication: 2016 Nov 28. - Publication Year :
- 2017
-
Abstract
- Objective: To investigate the frequency of the cytokine single nucleotide polymorphisms (SNPs) tumor necrosis factor (TNF)-α -308G > A, tumor growth factor (TGF)-β1 codon +10C > T, TGF-β1 codon +25G > C, interleukin (IL)-10 -1082A > G, IL-10 -819C > T, IL-10 -592C > A, IL-6 -174G > C, and IFN-γ +874T > A in a sample of healthy and cognitively impaired elderlies and to verify the probable association between these SNPs and cognitive and functional performance of subjects aged 75 years and above.<br />Methods: 259 Brazilian subjects were included, comprising 81 with cognitive impairment no dementia (CIND) and 54 demented seniors (together made up the cognitively impaired group, CI) and 124 age-matched and gender-matched cognitively healthy controls (CHS). The genotyping was performed by multiplex polymerase chain reaction. The cognitive performance was evaluated by Mini-Mental State Examination Brief Cognitive Screening Battery. The functional performance was accessed by Functional Activities Questionnaire.<br />Results: The CC <superscript>lower</superscript> genotype of TGF-β1 codon +25G > C was frequent in both patient groups. The TT <superscript>higher</superscript> genotype of INF-γ +874T > A was less frequent in the dementia group. IL-10 haplotypes of lower expression were more frequent among CIND and demented patients. In CI, individuals with genetic variants that produce higher expression of TGF-β1, INF-γ, and IL-10 showed better normalized cognitive performance. Additionally, the A <superscript>lower</superscript> allele of INF-γ +874T > A was related to worse functional performance in CI, while the A <superscript>lower</superscript> allele of TNF-α -308G > A was associated with better cognitive and functional scores in the CIND group.<br />Conclusions: Our findings suggest a potential role for certain cytokine SNPs in the development of CIND and dementia, which may influence the functional and cognitive performance of these patients. Copyright © 2016 John Wiley & Sons, Ltd.<br /> (Copyright © 2016 John Wiley & Sons, Ltd.)
- Subjects :
- Aged
Aged, 80 and over
Alleles
Brazil
Case-Control Studies
Female
Genotype
Humans
Interferon-gamma genetics
Interleukin-10 genetics
Interleukin-6 genetics
Male
Transforming Growth Factor beta1 genetics
Tumor Necrosis Factor-alpha genetics
Cognitive Dysfunction genetics
Cytokines genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1166
- Volume :
- 32
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International journal of geriatric psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 27891653
- Full Text :
- https://doi.org/10.1002/gps.4627