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Anxiety and Nicotine Dependence: Emerging Role of the Habenulo-Interpeduncular Axis.
- Source :
-
Trends in pharmacological sciences [Trends Pharmacol Sci] 2017 Feb; Vol. 38 (2), pp. 169-180. Date of Electronic Publication: 2016 Nov 24. - Publication Year :
- 2017
-
Abstract
- While innovative modern neuroscience approaches have aided in discerning brain circuitry underlying negative emotional behaviors including fear and anxiety responses, how these circuits are recruited in normal and pathological conditions remains poorly understood. Recently, genetic tools that selectively manipulate single neuronal populations have uncovered an understudied circuit, the medial habenula (mHb)-interpeduncular (IPN) axis, that modulates basal negative emotional responses. Interestingly, the mHb-IPN pathway also represents an essential circuit that signals heightened anxiety induced by nicotine withdrawal. Insights into how this circuit interconnects with regions more classically associated with anxiety, and how chronic nicotine exposure induces neuroadaptations resulting in an anxiogenic state, may thereby provide novel strategies and molecular targets for therapies that facilitate smoking cessation, as well as for anxiety relief.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Anxiety Disorders drug therapy
Corticotropin-Releasing Hormone physiology
Emotions
Humans
Mice
Receptors, Nicotinic physiology
Tobacco Use Disorder drug therapy
Ventral Tegmental Area physiology
Anxiety Disorders etiology
Habenula physiology
Interpeduncular Nucleus physiology
Tobacco Use Disorder etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3735
- Volume :
- 38
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Trends in pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 27890353
- Full Text :
- https://doi.org/10.1016/j.tips.2016.11.001