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Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii.
- Source :
-
Phytochemistry [Phytochemistry] 2017 Feb; Vol. 134, pp. 114-121. Date of Electronic Publication: 2016 Nov 23. - Publication Year :
- 2017
-
Abstract
- Eight triflavonoids, selagintriflavonoids A-H, were isolated from whole herbs of Selaginella doederleinii. The structures of compounds selagintriflavonoids A-C consisted of three naringenin units, whereas those of selagintriflavonoids D-H consisted of apigenin and two naringenin moieties. The structures and absolute configurations of the compounds were determined based on NMR, HRESIMS, and experimental and calculated electronic circular dichroism (ECD) data. The ability of the compounds to inhibit β-secretase (BACE1) was also evaluated. All compounds exhibited BACE1 inhibition with IC <subscript>50</subscript> values ranging from 0.75 to 46.99 μM. Selagintriflavonoid A exhibited the strongest inhibition (0.75 μM) and is thus a promising compound for treating Alzheimer's disease.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Apigenin
Cell Line, Tumor
Flavonoids chemistry
Humans
Inhibitory Concentration 50
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Alzheimer Disease drug therapy
Amyloid Precursor Protein Secretases antagonists & inhibitors
Flavonoids isolation & purification
Flavonoids pharmacology
Selaginellaceae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 134
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 27889245
- Full Text :
- https://doi.org/10.1016/j.phytochem.2016.11.011