Back to Search
Start Over
Prokineticin 2 Plays a Pivotal Role in Psoriasis.
- Source :
-
EBioMedicine [EBioMedicine] 2016 Nov; Vol. 13, pp. 248-261. Date of Electronic Publication: 2016 Oct 19. - Publication Year :
- 2016
-
Abstract
- Psoriasis is histologically characterized by keratinocytes (KC) hyperproliferation, inflammation, and increased angiogenesis, but the pathological factor responsible for these symptoms is unknown. Here, a neuroendocrine peptide (prokineticin 2, PK2), is highly expressed in human and mouse psoriatic skins but no significant change in other autoimmune diseases, suggesting that PK2 is a psoriasis-specific factor. Bacterial products significantly up-regulated PK2, implying that infection induces PK2 over-expression. PK2 promoted KC and macrophage to produce interleukin-1 (IL-1), the central player of inflammation and psoriasis, which acts on adjacent fibroblast to induce inflammatory cascades and KC hyperproliferation. IL-1 feeds back on macrophages to induce PK2 production to perpetuate PK2-IL-1 positive feedback loop. PK2 also promoted angiogenesis, another psoriatic symptom. In mouse models, PK2 over-expression aggravated psoriasis while its knock-down inhibited pathological development. The results indicate that PK2 over-production perpetuates psoriatic symptoms by creating PK-2-IL-1 vicious loop. PK2 is a central player in psoriasis and a promising psoriasis-specific target.<br /> (Copyright © 2016. Published by Elsevier B.V.)
- Subjects :
- Adult
Animals
Biopsy
Cell Line
Cell Proliferation
Cytokines metabolism
DNA-Binding Proteins metabolism
Disease Models, Animal
Female
Fibroblasts metabolism
Gastrointestinal Hormones blood
Gastrointestinal Hormones genetics
Gene Knockdown Techniques
Humans
Keratinocytes metabolism
Macrophages immunology
Macrophages metabolism
Male
Mice
Mice, Transgenic
Middle Aged
Mitogen-Activated Protein Kinases metabolism
Models, Biological
Neovascularization, Pathologic genetics
Neovascularization, Pathologic metabolism
Neuropeptides blood
Neuropeptides genetics
Psoriasis diagnosis
Psoriasis genetics
Severity of Illness Index
Signal Transduction
Skin metabolism
Skin pathology
Young Adult
Gastrointestinal Hormones metabolism
Neuropeptides metabolism
Psoriasis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2352-3964
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- EBioMedicine
- Publication Type :
- Academic Journal
- Accession number :
- 27887936
- Full Text :
- https://doi.org/10.1016/j.ebiom.2016.10.022