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Incidence of Guillain-Barré syndrome during a nationwide oral poliovirus vaccine campaign.
- Source :
-
Neurology [Neurology] 1989 Aug; Vol. 39 (8), pp. 1034-6. - Publication Year :
- 1989
-
Abstract
- Concomitant with a nationwide oral poliovirus vaccine (OPV) campaign in Finland in 1985, an unexpected rise in the number of patients hospitalized with the Guillain-Barré syndrome (GBS) occurred. An analysis based on hospital records covering a population of 1.17 million and 6 years revealed a significantly increased incidence of GBS coinciding with the OPV campaign. We carefully examined 10 cases with onset of GBS within 10 weeks after immunization. Only 4 patients could recall recent symptomatic infection, and we found no specific agent in these cases. Our study suggests that live-attenuated polioviruses may, like other infectious viruses, sometimes trigger the GBS.
Details
- Language :
- English
- ISSN :
- 0028-3878
- Volume :
- 39
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 2788248
- Full Text :
- https://doi.org/10.1212/wnl.39.8.1034