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Increase in activity of Na + , K + -ATPase by Porphyrin compounds as treatment for Dysnatremias caused by Diabetes Mellitus.
- Source :
-
Pakistan journal of medical sciences [Pak J Med Sci] 2016 Sep-Oct; Vol. 32 (5), pp. 1131-1134. - Publication Year :
- 2016
-
Abstract
- Objective: The aim of this study was to test the action of Porphyrin compounds, Tetraphenylporphine sulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS), on Na+, K+ -ATPase of cell membrane of erythrocytes.<br />Methods: Enzymatic assays, measuring the amount of inorganic phosphate produced, were used to estimate the activity of Na <superscript>+</superscript> , K <superscript>+</superscript> -ATPase.<br />Results: The results show that Porphyrin compounds exert an insulin-like effect on Na <superscript>+</superscript> , K <superscript>+</superscript> -ATPase. They act by increasing the activity of the membrane-bound enzyme.<br />Conclusion: All the three Porphyrin compounds increased the activity of erythrocyte Na <superscript>+</superscript> , K <superscript>+</superscript> -ATPase. The exact mechanism of action of these compounds is not clear.
Details
- Language :
- English
- ISSN :
- 1682-024X
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pakistan journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 27882008
- Full Text :
- https://doi.org/10.12669/pjms.325.11530