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The treatment of bacterial vaginosis in pregnancy with clindamycin to reduce the risk of infection-related preterm birth: a response to the Danish Society of Obstetrics and Gynecology guideline group's clinical recommendations.
- Source :
-
Acta obstetricia et gynecologica Scandinavica [Acta Obstet Gynecol Scand] 2017 Feb; Vol. 96 (2), pp. 139-143. Date of Electronic Publication: 2017 Jan 13. - Publication Year :
- 2017
-
Abstract
- Preterm birth is the major cause of perinatal mortality and morbidity worldwide. Infection/inflammation is responsible for a significant percentage of preterm birth, particularly at early gestations. A recent clinical recommendation by a guidelines group of the Danish Society of Obstetrics and Gynecology advised against the use of clindamycin for the treatment of bacterial vaginosis in pregnancy to reduce the risk of spontaneous preterm birth based on lack of evidence of efficacy. We believe that the evidence for the use of clindamycin for this indication is robust and that this recommendation was reached erroneously on the basis of flawed inclusion criteria: the inclusion of an unpublished study with poorly diagnosed bacterial vaginosis and the exclusion of an important pivotal study on the use of clindamycin in early pregnancy for the prevention of preterm birth. Had these errors been corrected, the conclusions would have been different.<br /> (© 2016 Nordic Federation of Societies of Obstetrics and Gynecology.)
- Subjects :
- Abortion, Spontaneous microbiology
Abortion, Spontaneous prevention & control
Clindamycin pharmacology
Female
Humans
Infant, Low Birth Weight
Infant, Newborn
Metronidazole pharmacology
Metronidazole therapeutic use
Pregnancy
Premature Birth microbiology
Research Design
Vaginosis, Bacterial complications
Anti-Bacterial Agents therapeutic use
Clindamycin therapeutic use
Practice Guidelines as Topic
Pregnancy Complications, Infectious drug therapy
Premature Birth prevention & control
Vaginosis, Bacterial drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0412
- Volume :
- 96
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta obstetricia et gynecologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 27874978
- Full Text :
- https://doi.org/10.1111/aogs.13065