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New insights into the immunopathogenesis of systemic lupus erythematosus.
- Source :
-
Nature reviews. Rheumatology [Nat Rev Rheumatol] 2016 Nov 22; Vol. 12 (12), pp. 716-730. - Publication Year :
- 2016
-
Abstract
- The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes contributions from the environment, stochastic factors, and genetic susceptibility. Great gains have been made in understanding SLE through the use of genetic variant identification, mouse models, gene expression studies, and epigenetic analyses. Collectively, these studies support the concept that defective clearance of immune complexes and biological waste (such as apoptotic cells), neutrophil extracellular traps, nucleic acid sensing, lymphocyte signalling, and interferon production pathways are all central to loss of tolerance and tissue damage. Increased understanding of the pathogenesis of SLE is driving a renewed interest in targeted therapy, and researchers are now on the verge of developing targeted immunotherapy directed at treating either specific organ system involvement or specific subsets of patients with SLE. Accordingly, this Review places these insights within the context of our current understanding of the pathogenesis of SLE and highlights pathways that are ripe for therapeutic targeting.
- Subjects :
- Animals
Apoptosis immunology
B-Lymphocytes immunology
Dendritic Cells immunology
Disease Models, Animal
Epigenesis, Genetic
Genetic Predisposition to Disease
Humans
Immune Tolerance immunology
Immunotherapy
Interferons immunology
Lupus Erythematosus, Cutaneous immunology
Lupus Erythematosus, Systemic genetics
Lupus Erythematosus, Systemic therapy
Lupus Nephritis immunology
Lupus Vasculitis, Central Nervous System immunology
Mice
Myeloid Cells immunology
Signal Transduction
T-Lymphocytes immunology
Toll-Like Receptors immunology
Antigen-Antibody Complex immunology
Autoantibodies immunology
Extracellular Traps immunology
Lupus Erythematosus, Systemic immunology
Lymphocytes immunology
MicroRNAs genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1759-4804
- Volume :
- 12
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature reviews. Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 27872476
- Full Text :
- https://doi.org/10.1038/nrrheum.2016.186