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Associations between former exposure to manganese and olfaction in an elderly population: Results from the Heinz Nixdorf Recall Study.
- Source :
-
Neurotoxicology [Neurotoxicology] 2017 Jan; Vol. 58, pp. 58-65. Date of Electronic Publication: 2016 Nov 16. - Publication Year :
- 2017
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Abstract
- Occupational exposure to manganese (Mn) has been associated with impairments in olfaction and motor functions, but it has yet to be determined if such effects persist upon cessation of exposure. The objective of this study was to evaluate the influence of former occupational Mn exposure on olfaction within the framework of a prospective cohort study among an elderly German population. Information on job tasks with recognized Mn exposure and data on odor identification assessed with Sniffin' sticks was collected during the second follow-up of the Heinz Nixdorf Recall Study. The study population consisted of 1385 men aged 55-86 years, 354 of whom ever worked in jobs with potential Mn exposure (median 58.3μg/m <superscript>3</superscript> years, interquartile range 19.0-185μg/m <superscript>3</superscript> years). Multiple exposure measures, including job tasks, cumulative Mn exposure, and Mn determined in blood samples (MnB) archived at baseline, were used to estimate effects of Mn on olfaction. Having ever worked as welder was associated with better olfaction compared to other blue-collar workers without Mn exposure. Blue-collar workers identified less odors in comparison to white-collar workers. Concentrations of previous Mn exposure >185μg/m <superscript>3</superscript> years or MnB ≥15μg/L were not associated with impaired olfaction. In addition to a strong age effect, participants with lower occupational qualification identified less odors. We found no relevant association of former Mn exposure at relatively low levels with impaired olfaction. Possible neurotoxic Mn effects may not be persistent after cessation.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Cohort Studies
Community Health Planning
Humans
Iron metabolism
Liver metabolism
Liver pathology
Male
Manganese blood
Middle Aged
Statistics, Nonparametric
Aging
Manganese toxicity
Occupational Exposure adverse effects
Odorants
Olfaction Disorders chemically induced
Olfaction Disorders epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9711
- Volume :
- 58
- Database :
- MEDLINE
- Journal :
- Neurotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 27865828
- Full Text :
- https://doi.org/10.1016/j.neuro.2016.11.005