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Immune complexes and complexity: investigating mechanisms of renal disease.
- Source :
-
International urology and nephrology [Int Urol Nephrol] 2017 Apr; Vol. 49 (4), pp. 735-739. Date of Electronic Publication: 2016 Nov 18. - Publication Year :
- 2017
-
Abstract
- The deposition of immune complexes is the causal factor in distinct renal pathologies, e.g., lupus nephritis and membranous nephritis. The location of these deposits within a tissue biopsy is often the key to establishing a diagnosis. However, how immune complexes come to be deposited below the vascular endothelium was, until now, a mystery, as was their contribution to inducing inflammation. A recent paper in Cell by Stamatiades et al. (Cell 164(4):991-1003, 2016) demonstrates the active transport of immune complexes by the vascular endothelial cells and an Fc receptor-dependent uptake by tissue-resident macrophages. This leads to the activation of these macrophages and the release of pro-inflammatory cytokines, which in turn recruits immune cells from the blood into the kidney. The identification of these mechanisms should lead to a better stratification of kidney diseases and hopefully to the development of specific therapies.
Details
- Language :
- English
- ISSN :
- 1573-2584
- Volume :
- 49
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International urology and nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 27864659
- Full Text :
- https://doi.org/10.1007/s11255-016-1450-5