The effects of aluminium on brain gangliosides in uraemic rats treated with 24R,25-dihydroxyvitamin D3.

Authors :: Vukicević S
Kracun I
Stavljenić A
Kelović Z
Krempien B
Rösner H
Source :: Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 1989 Jan-Feb; Vol. 15 (1), pp. 55-62.
Publication Year :: 1989
Abstract: The administration of aluminium to uraemic rats leads to aluminium accumulation in different brain regions. Aluminium intoxication significantly alters brain gangliosides, the content of which is increased in uraemic animals. This phenomenon can be prevented by administration of 24R,25-dihydroxyvitamin D3 (24,25(OH)2D3). Our results could possibly find an application in the prevention of aluminium-induced encephalopathy in patients on haemodialysis.

Subjects :: 24,25-Dihydroxyvitamin D 3
Aluminum pharmacokinetics
Animals
Brain Diseases drug therapy
Brain Diseases metabolism
Disease Models, Animal
Rats
Aluminum toxicity
Brain Diseases chemically induced
Dihydroxycholecalciferols therapeutic use
Gangliosides metabolism
Uremia metabolism

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