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Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology.
- Source :
-
The FEBS journal [FEBS J] 2017 Jan; Vol. 284 (1), pp. 10-26. Date of Electronic Publication: 2016 Dec 07. - Publication Year :
- 2017
-
Abstract
- Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and, as such, are intrinsically involved in cancer initiation and progression. In this minireview, we will address novel functions of biglycan and decorin in inflammation and autophagy, and analyze new emerging signaling events triggered by these proteoglycans, which directly or indirectly modulate these processes. We will critically discuss the dual role of proteoglycan-driven inflammation and autophagy in tumor biology, and delineate the potential mechanisms through which soluble extracellular matrix constituents affect the microenvironment associated with inflammatory and neoplastic diseases.<br /> (© 2016 Federation of European Biochemical Societies.)
- Subjects :
- Autophagy
Cytokines genetics
Cytokines metabolism
Decorin genetics
Endothelial Cells metabolism
Endothelial Cells pathology
ErbB Receptors genetics
ErbB Receptors metabolism
Extracellular Matrix metabolism
Humans
Inflammation
Neoplasms genetics
Neoplasms pathology
Neoplastic Cells, Circulating metabolism
Neoplastic Cells, Circulating pathology
Neovascularization, Pathologic genetics
Neovascularization, Pathologic pathology
Proto-Oncogene Proteins c-met genetics
Proto-Oncogene Proteins c-met metabolism
Signal Transduction
Vascular Endothelial Growth Factor A genetics
Vascular Endothelial Growth Factor A metabolism
Biglycan metabolism
Decorin metabolism
Gene Expression Regulation, Neoplastic
Neoplasms metabolism
Neovascularization, Pathologic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1742-4658
- Volume :
- 284
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The FEBS journal
- Publication Type :
- Academic Journal
- Accession number :
- 27860287
- Full Text :
- https://doi.org/10.1111/febs.13963