A Powerful CD8 + T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant.

Authors :: Luo Z
Wu Q
Yang C
Wang H
He T
Wang Y
Wang Z
Chen H
Li X
Gong C
Yang Z
Source :: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2017 Feb; Vol. 29 (5). Date of Electronic Publication: 2016 Nov 14.
Publication Year :: 2017
Abstract: A novel vaccine adjuvant based on a supramolecular hydrogel of a D-tetra-peptide is reported. Antigens can be easily incorporated into the hydrogel by a vortex or by gently shaking before injection. The vaccines can stimulate strong CD8+ T-cell responses, which significantly inhibits tumor growth. This novel adjuvant is expected to enable a wide range of sub-unit vaccines and help the production of antibodies.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Adjuvants, Immunologic
Hydrogels
Peptides
Vaccines
CD8-Positive T-Lymphocytes

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