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CD45-mediated control of TCR tuning in naïve and memory CD8 + T cells.
- Source :
-
Nature communications [Nat Commun] 2016 Nov 14; Vol. 7, pp. 13373. Date of Electronic Publication: 2016 Nov 14. - Publication Year :
- 2016
-
Abstract
- Continuous contact with self-major histocompatibility complex (MHC) ligands is essential for survival of naïve T cells but not memory cells. This surprising finding implies that T cell subsets may vary in their relative T-cell receptor (TCR) sensitivity. Here we show that in CD8 <superscript>+</superscript> T cells TCR sensitivity correlates inversely with levels of CD5, a marker for strong self-MHC reactivity. We also show that TCR sensitivity is lower in memory CD8 <superscript>+</superscript> T cells than naïve cells. In both situations, TCR hypo-responsiveness applies only to short-term TCR signalling events and not to proliferation, and correlates directly with increased expression of a phosphatase, CD45 and reciprocal decreased expression of activated LCK. Inhibition by high CD45 on CD8 <superscript>+</superscript> T cells may protect against overt TCR auto-MHC reactivity, while enhanced sensitivity to cytokines ensures strong responses to foreign antigens.
- Subjects :
- Animals
CD5 Antigens immunology
CD5 Antigens metabolism
CD8-Positive T-Lymphocytes metabolism
Cells, Cultured
Interleukin-2 genetics
Interleukin-2 immunology
Interleukin-2 metabolism
Leukocyte Common Antigens metabolism
Lymphocyte Activation immunology
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Receptors, Antigen, T-Cell metabolism
CD8-Positive T-Lymphocytes immunology
Immunologic Memory immunology
Leukocyte Common Antigens immunology
Receptors, Antigen, T-Cell immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 27841348
- Full Text :
- https://doi.org/10.1038/ncomms13373