A new spectinabilin derivative with cytotoxic activity from ant-derived Streptomyces sp. 1H-GS5.

Authors :: Liu CX
Liu SH
Zhao JW
Zhang J
Wang XJ
Li JS
Wang JD
Xiang WS
Source :: Journal of Asian natural products research [J Asian Nat Prod Res] 2017 Sep; Vol. 19 (9), pp. 924-929. Date of Electronic Publication: 2016 Nov 13.
Publication Year :: 2017
Abstract: A new spectinabilin derivative (1) was isolated from the fermentation broth of the ant-derived Streptomyces sp. 1H-GS5, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human tumor cell lines A549, HCT-116, and HepG2 with IC <subscript>50</subscript> values of 9.7, 12.8, and 9.1 μg/ml, respectively, which was relative higher than that of spectinabilin.

Subjects :: Animals
Antineoplastic Agents chemistry
Drug Screening Assays, Antitumor
HCT116 Cells
Hep G2 Cells
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Peptide Fragments chemistry
Pyrones chemistry
Substance P analogs & derivatives
Substance P chemistry
Antineoplastic Agents isolation & purification
Antineoplastic Agents pharmacology
Ants microbiology
Pyrones isolation & purification
Pyrones pharmacology
Streptomyces chemistry

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