PIN1 in breast development and cancer: a clinical perspective.

Authors :: Rustighi A
Zannini A
Campaner E
Ciani Y
Piazza S
Del Sal G
Source :: Cell death and differentiation [Cell Death Differ] 2017 Feb; Vol. 24 (2), pp. 200-211. Date of Electronic Publication: 2016 Nov 11.
Publication Year :: 2017
Abstract: Mammary gland development, various stages of mammary tumorigenesis and breast cancer progression have the peptidyl-prolyl cis/trans isomerase PIN1 at their centerpiece, in virtue of the ability of this unique enzyme to fine-tune the dynamic crosstalk between multiple molecular pathways. PIN1 exerts its action by inducing conformational and functional changes on key cellular proteins, following proline-directed phosphorylation. Through this post-phosphorylation signal transduction mechanism, PIN1 controls the extent and direction of the cellular response to a variety of inputs, in physiology and disease. This review discusses PIN1's roles in normal mammary development and cancerous progression, as well as the clinical impact of targeting this enzyme in breast cancer patients.<br />Competing Interests: The authors declare no conflict of interest.