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X-Linked miRNAs Associated with Gender Differences in Rheumatoid Arthritis.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2016 Nov 08; Vol. 17 (11). Date of Electronic Publication: 2016 Nov 08. - Publication Year :
- 2016
-
Abstract
- Rheumatoid arthritis (RA) is an autoimmune disease that predominantly affects women. MicroRNAs have emerged as crucial regulators of the immune system, whose expression is deregulated in RA. We aimed at quantifying the expression level of 14 miRNAs located on the X chromosome and at identifying whether differences are associated with disease and/or sex. A case-control study of 21 RA patients and 22 age- and sex-matched healthy controls was performed on peripheral blood mononuclear cells. The expression level of five miRNAs (miR-221, miR-222, miR-532, miR-106a, and miR-98) was significantly different between RA and controls when stratifying by sex, and the expression level of four miRNAs (miR-222, miR-532, miR-98, and miR-92a) was significantly different between RA females and males. The expression quantitative trait loci (eQTL) analysis revealed a significant gender effect of the FoxP3 promoter polymorphism rs3761548A/C on miR-221, miR-222 and miR-532 expression levels, and of the FoxP3 polymorphism rs2232365A/G on miR-221 expression levels in PBMC of RA patients. These data further support the involvement of the X chromosome in RA susceptibility. X-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Adult
Aged
Arthritis, Rheumatoid genetics
Arthritis, Rheumatoid metabolism
Arthritis, Rheumatoid pathology
Case-Control Studies
Female
Forkhead Transcription Factors metabolism
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
Leukocytes, Mononuclear
Male
MicroRNAs metabolism
Middle Aged
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Quantitative Trait Loci
Sex Factors
Arthritis, Rheumatoid diagnosis
Chromosomes, Human, X
Forkhead Transcription Factors genetics
MicroRNAs genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 17
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 27834806
- Full Text :
- https://doi.org/10.3390/ijms17111852