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The H blood group system.
- Source :
-
Immunohematology [Immunohematology] 2016 Sep; Vol. 32 (3), pp. 112-118. - Publication Year :
- 2016
-
Abstract
- The H blood group system, ISBT symbol H (018), consists of a single antigen (H) defined by a terminal fucose residue found on red blood cells and in secretions formed by the action of α-1,2-fucosyltransferases 1 (α2FucT1) and 2 (α2FucT2), respectively. Mutant alleles of the corresponding FUT1 and FUT2 genes result in either a H– phenotype (Bombay phenotype, Oh) or a weak H phenotype (para-Bombay, H+w). In addition, the FUT2 gene is the molecular basis of the secretor (Se) status, and homozygosity or compound heterozygosity for null alleles is associated with the nonsecretor (se) status. H– individuals have natural anti-H (mostly IgM), which can cause severe hemolytic transfusion reactions with intravascular hemolysis.
- Subjects :
- Alleles
Antigens, Bacterial biosynthesis
Autoantibodies immunology
Blood Group Incompatibility
Carbohydrate Sequence
Chromosomes, Human, Pair 19 genetics
Erythrocytes immunology
Ethnicity genetics
Fucose metabolism
Genetic Association Studies
Glycosylation
Hemolysis
Humans
Immunoglobulin M immunology
India
Isoantibodies immunology
Mutation
Protein Processing, Post-Translational
Reunion
Transfusion Reaction
Galactoside 2-alpha-L-fucosyltransferase
ABO Blood-Group System genetics
ABO Blood-Group System immunology
Antigens, Bacterial immunology
Fucosyltransferases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0894-203X
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Immunohematology
- Publication Type :
- Academic Journal
- Accession number :
- 27834485