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Predictive and Prognostic Value of Early Disease Progression by PET Evaluation in Advanced Non-Small Cell Lung Cancer.
- Source :
-
Oncology [Oncology] 2017; Vol. 92 (1), pp. 39-47. Date of Electronic Publication: 2016 Nov 11. - Publication Year :
- 2017
-
Abstract
- Objective: To assess the predictive and prognostic value of progressive metabolic disease (PMD) by the use of early 18Fluorodeoxyglucose positron emission tomography (18FDG-PET) in patients with clinical stage IV non-small cell lung cancer (NSCLC) treated with first-line chemotherapy.<br />Methods: An 18FDG-PET performed following the first cycle of chemotherapy (PET-1) was compared with a pretreatment 18FDG-PET (PET-0) and a computed tomography (CT) scan after the third cycle (CT-3). The primary endpoint was the positive predictive value (PPV) of PMD. Secondary endpoints included the prognostic value of PMD.<br />Results: Eleven of 38 patients (29%) had a PMD by PET-1, and 15 (39%), including all patients with a PMD, experienced a progressive disease by CT-3. The PPV of PMD was 100% according to both the European Organization for Research and Treatment of Cancer (EORTC) criteria and the PET Response Criteria In Solid Tumors (PERCIST) (p value for both, <0.0001). Patients with a PMD by PET-1 had a median overall survival of 7.0 months versus 14.0 months for those without a PMD (p = 0.04, according to the EORTC criteria).<br />Conclusions: Early 18FDG-PET assessment deserves further investigation for the identification of NSCLC patients who do not benefit from first-line chemotherapy.<br /> (© 2016 S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Bevacizumab administration & dosage
Carboplatin administration & dosage
Carcinoma, Non-Small-Cell Lung drug therapy
Carcinoma, Non-Small-Cell Lung pathology
Cisplatin administration & dosage
Disease Progression
Female
Fluorodeoxyglucose F18 analysis
Humans
Lung Neoplasms drug therapy
Lung Neoplasms pathology
Male
Middle Aged
Neoplasm Staging
Predictive Value of Tests
Prognosis
Radiopharmaceuticals analysis
Tomography, X-Ray Computed methods
Carcinoma, Non-Small-Cell Lung diagnostic imaging
Lung Neoplasms diagnostic imaging
Positron-Emission Tomography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0232
- Volume :
- 92
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 27832654
- Full Text :
- https://doi.org/10.1159/000448005