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Viral Suppression and Retention in Care up to 5 Years After Initiation of Lifelong ART During Pregnancy (Option B+) in Rural Uganda.
- Source :
-
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2017 Mar 01; Vol. 74 (3), pp. 279-284. - Publication Year :
- 2017
-
Abstract
- Background: Lifelong antiretroviral therapy (ART) is recommended for all HIV-infected pregnant women, but early studies suggest that women often drop out of care postpartum and data are limited on virologic outcomes.<br />Methods: We evaluated viral suppression (primary outcome) and retention in care up to 5 years after ART initiation among HIV-infected women who started lifelong ART during pregnancy, irrespective of CD4 count, in a study in rural Uganda (NCT00993031). Participants were followed in the study for up to 1 year postpartum, then referred to clinics in surrounding communities. A random sample (N = 200) was invited to participate in a cross-sectional follow-up study after completing the trial, involving one visit for a questionnaire and pregnancy and HIV-1 RNA testing. Retention in care was defined as having attended an HIV clinic in the last 90 days. Logistic regression models were used to examine factors associated with viral suppression (HIV-1 RNA <400 copies/ml) at follow-up.<br />Results: One hundred fifty women (75%) were successfully contacted for follow-up at a median of 4.2 years after starting ART; 135 were retained in care [90%, 95% confidence interval (CI): 84.0% to 94.3%] and 121 demonstrated viral suppression (80.7%, 95% CI: 73.4% to 86.7%). Women who had disclosed their HIV status to their primary partner had greater odds of viral suppression (adjusted odds ratio: 4.51, 95% CI: 1.02 to 19.8).<br />Conclusions: High rates of viral suppression can be achieved up to 5 years after initiating ART during pregnancy among women retained in care. Interventions to facilitate disclosure may improve long-term outcomes among women who initiate ART during pregnancy under universal treatment.<br />Competing Interests: Gilead donates medications for participants in a separate NIH-funded study led by D.V.H. but provides no financial support. All other authors declare no competing interests.
- Subjects :
- Adult
Cross-Sectional Studies
Female
Follow-Up Studies
HIV-1 isolation & purification
Humans
Pregnancy
RNA, Viral blood
Rural Population
Surveys and Questionnaires
Treatment Outcome
Uganda
Anti-Retroviral Agents therapeutic use
HIV Infections drug therapy
Medication Adherence
Pregnancy Complications, Infectious drug therapy
Sustained Virologic Response
Subjects
Details
- Language :
- English
- ISSN :
- 1944-7884
- Volume :
- 74
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Publication Type :
- Academic Journal
- Accession number :
- 27828878
- Full Text :
- https://doi.org/10.1097/QAI.0000000000001228