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Dietary Fructose-Induced Hepatic Injury in Male and Female Rats: Influence of Resveratrol.
- Source :
-
Drug research [Drug Res (Stuttg)] 2017 Feb; Vol. 67 (2), pp. 103-110. Date of Electronic Publication: 2016 Nov 07. - Publication Year :
- 2017
-
Abstract
- Purpose: Relatively little is known about gender-dependent susceptibility to hepatic injury induced by nutritional factors. In the current study, we investigated dietary fructose-induced hepatic degeneration and roles of endothelial nitric oxide synthase (eNOS), insulin receptor (IRβ) and substrate-1 (IRS-1) expressions in association with inflammatory markers in male and female rats. Moreover, we examined potential effect of resveratrol on fructose-induced changes. Methods: Male and female rats were divided into 4 groups as control, resveratrol, fructose and resveratrol plus fructose. All rats were fed with a standard diet with or without resveratrol (500 mg/kg). Fructose was given as 10% in drinking waterfor 24 weeks. Results: Long-term dietary fructose caused parenchymal degeneration and hyperemia in association with impaired eNOS mRNA/protein expressions in liver of male and female rats. This dietary intervention also led to increases in hepatic triglyceride content, TNFα and IL-1β levels in both genders. Gender-related differences to consequence of fructose consumption were not obvious. Resveratrol supplementation markedly attenuated hepatic degeneration, hyperemia and triglyceride content in association with reduced TNFα and IL-1β levels, but enhanced IRβ mRNA and IRS-1 protein, in male and female rats upon fructose feeding. Conclusion: Long-term dietary fructose causes hepatic degeneration possibly via a decrease in eNOS, but increase in TNFα and IL-1β, in both genders. Resveratrol supplementation improved fructose-induced hepatic injury.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Animals
Antioxidants administration & dosage
Biomarkers blood
Body Weight drug effects
Female
Fructose administration & dosage
High Fructose Corn Syrup administration & dosage
High Fructose Corn Syrup adverse effects
Insulin metabolism
Insulin Receptor Substrate Proteins metabolism
Interleukin-1beta metabolism
Liver enzymology
Liver pathology
Male
Non-alcoholic Fatty Liver Disease pathology
Rats
Rats, Wistar
Receptor, Insulin metabolism
Resveratrol
Signal Transduction
Stilbenes administration & dosage
Triglycerides metabolism
Tumor Necrosis Factor-alpha metabolism
Antioxidants pharmacology
Diet, Carbohydrate Loading adverse effects
Fructose adverse effects
Liver drug effects
Nitric Oxide Synthase Type III metabolism
Non-alcoholic Fatty Liver Disease chemically induced
Non-alcoholic Fatty Liver Disease enzymology
Stilbenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2194-9387
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Drug research
- Publication Type :
- Academic Journal
- Accession number :
- 27824430
- Full Text :
- https://doi.org/10.1055/s-0042-118386