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Regulation of lipid metabolism via a connection between the endoplasmic reticulum and lipid droplets.
- Source :
-
Anatomical science international [Anat Sci Int] 2017 Jan; Vol. 92 (1), pp. 50-54. Date of Electronic Publication: 2016 Nov 07. - Publication Year :
- 2017
-
Abstract
- Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids to regulate cellular lipid homeostasis. Fatty acids are packaged as triglyceride and cholesterol ester into endoplasmic reticulum (ER) membranes to synthesize LDs. Cytosolic LDs move dynamically and interact with organelles, including other LDs. In this process, functional proteins for metabolism are also transferred to LDs. In this review, I focus on interactions between the ER and LDs related to lipid metabolism.
- Subjects :
- Endoplasmic Reticulum physiology
Humans
Lipid Droplets physiology
Lipolysis
Mitochondrial Membranes metabolism
Organelles
Perilipin-1 metabolism
Perilipin-1 physiology
Perilipins metabolism
Perilipins physiology
Phosphatidylcholines biosynthesis
Protein Binding
Proteolysis
Endoplasmic Reticulum metabolism
Lipid Droplets metabolism
Lipid Metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1447-073X
- Volume :
- 92
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anatomical science international
- Publication Type :
- Academic Journal
- Accession number :
- 27822589
- Full Text :
- https://doi.org/10.1007/s12565-016-0378-2