Two new phenylpropanoid glycosides from the aerial parts of Lespedeza cuneata .

Two new phenylpropanoid glycosides named cuneataside E ( 1 ) and cuneataside F ( 2 ), were isolated from the aerial parts of Lespedeza cuneata (Dum. Cours.) G. Don, whose structures were E and Z isomer, respectively. Their structures were elucidated on the basis of comprehensive spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR). In in vitro bioassays at 10 μmol/L, compound 1 showed moderate hepatoprotective activity against N -acetyl- p -aminophenol (APAP)-induced toxicity in HeG2 cells.