Back to Search
Start Over
Macrophage colony-stimulating factor expressed in non-cancer tissues provides predictive powers for recurrence in hepatocellular carcinoma.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2016 Oct 21; Vol. 22 (39), pp. 8779-8789. - Publication Year :
- 2016
-
Abstract
- Aim: To investigate the role of macrophage colony-stimulating factor (M-CSF) in patients with hepatocellular carcinoma (HCC) after surgery.<br />Methods: Expression of M-CSF, distribution of M2 macrophages (MΦs), and angiogenesis were assessed in the liver, including tumors and peritumoral liver tissues. The prognostic power of these factors was assessed. Mouse isolated hepatic MΦs or monocytes were cultured with media containing M-CSF. The concentration of vascular endothelial growth factor (VEGF) in media was assessed. Furthermore, the role of the M-CSF-matured hepatic MΦs on proliferation of the vascular endothelial cell (VEC) was investigated.<br />Results: A strong correlation between the expressions of M-CSF and CD163 was observed in the peritumoral area. Also, groups with high density of M-CSF, CD163 or CD31 showed a significantly shorter time to recurrence (TTR) than low density groups. Multivariate analysis revealed the expression of M-CSF or hepatic M2MΦs in the peritumoral area as the most crucial factor responsible for shorter TTR. Moreover, the expression of M-CSF and hepatic M2MΦs in the peritumoral area had better predictable power of overall survival. Values of VEGF in culture media were significantly greater in the hepatic MΦs compared with the monocytes. Proliferation of the VEC was greatest in the cells co-cultured with hepatic MΦs when M-CSF was present in media.<br />Conclusion: M-CSF increases hepatocarcinogenesis, most likely by enhancing an angiogenic factor derived from hepatic MΦ and could be a useful target for therapy against HCC.<br />Competing Interests: Conflict-of-interest statement: There are no conflicts-of-interest on this study.
- Subjects :
- Adult
Aged
Aged, 80 and over
Animals
Antigens, CD metabolism
Antigens, Differentiation, Myelomonocytic metabolism
Biomarkers, Tumor metabolism
Carcinoma, Hepatocellular metabolism
Cell Proliferation
Disease-Free Survival
Endothelial Cells cytology
Female
Humans
Liver metabolism
Liver Neoplasms metabolism
Macrophages metabolism
Male
Mice
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local
Neovascularization, Pathologic pathology
Platelet Endothelial Cell Adhesion Molecule-1 metabolism
Predictive Value of Tests
Prognosis
Receptors, Cell Surface metabolism
Retrospective Studies
Vascular Endothelial Growth Factor A metabolism
Carcinoma, Hepatocellular diagnosis
Liver Neoplasms diagnosis
Macrophage Colony-Stimulating Factor metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 22
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 27818593
- Full Text :
- https://doi.org/10.3748/wjg.v22.i39.8779