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Changes in triglycerides and high-density lipoprotein cholesterol may precede peripheral insulin resistance, with 2-h insulin partially mediating this unidirectional relationship: a prospective cohort study.
- Source :
-
Cardiovascular diabetology [Cardiovasc Diabetol] 2016 Nov 04; Vol. 15 (1), pp. 154. Date of Electronic Publication: 2016 Nov 04. - Publication Year :
- 2016
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Abstract
- Background: Results of longitudinal researches regarding the temporal relationship between dyslipidemia and insulin resistance (IR) are inconsistent. This study assessed temporal relationships of blood lipids with IR and determined whether there are any mediating effects existed in these temporal relationships.<br />Methods: This study examined a longitudinal cohort of 3325 subjects aged 20-74 years from China with an average of 4.2 years follow-up. Measurements of fasting blood lipids, as well as fasting and 2-h serum glucose and insulin, were obtained at two time points. The Gutt index and HOMA-IR were calculated as indicators of peripheral IR and hepatic IR. A cross-lagged path analysis was performed to examine the temporal relationships between blood lipids and IR. A mediation analysis was used to examine mediating effect.<br />Results: After adjusting for covariates, the cross-lagged path coefficients from baseline TG and HDL-C to follow-up Gutt index were significantly greater than those from baseline Gutt index to follow-up TG and HDL-C (β <subscript>1</subscript>  = -0.131 vs β <subscript>2</subscript>  = -0.047, P < 0.001 for TG; β <subscript>1</subscript>  = 0.134 vs β <subscript>2</subscript>  = 0.023, P < 0.001 for HDL-C). The path coefficients from baseline TG and HDL-C to follow-up 2-h insulin were significantly greater than those from baseline 2-h insulin to follow-up TG and HDL-C (β <subscript>1</subscript>  = 0.125 vs β <subscript>2</subscript>  = 0.040, P < 0.001 for TG; β <subscript>1</subscript>  = -0.112 vs β <subscript>2</subscript>  = -0.026, P < 0.001 for HDL-C). 2-h insulin partially mediated the effect of TG/HDL-C on Gutt index with a 59.3% mediating effect for TG and 61.0% for HDL-C.<br />Conclusions: These findings provide strong evidence that dyslipidemia probably precede peripheral IR and that 2-h insulin partially mediates this unidirectional temporal relationship.
- Subjects :
- Adult
Aged
Biomarkers blood
China
Disease Progression
Dyslipidemias diagnosis
Female
Humans
Linear Models
Longitudinal Studies
Male
Middle Aged
Multivariate Analysis
Prognosis
Prospective Studies
Time Factors
Young Adult
Blood Glucose metabolism
Cholesterol, HDL blood
Dyslipidemias blood
Insulin blood
Insulin Resistance
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2840
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 27814764
- Full Text :
- https://doi.org/10.1186/s12933-016-0469-3