Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia.

Authors :: Mettananda S
Fisher CA
Sloane-Stanley JA
Taylor S
Oppermann U
Gibbons RJ
Higgs DR
Source :: Haematologica [Haematologica] 2017 Mar; Vol. 102 (3), pp. e80-e84. Date of Electronic Publication: 2016 Nov 03.
Publication Year :: 2017

Subjects :: Antigens, CD34 genetics
Antigens, CD34 metabolism
Butyric Acid pharmacology
Cell Culture Techniques
Erythroid Cells cytology
Erythroid Cells metabolism
Gene Expression Profiling
Gene Expression Regulation
Histone Demethylases antagonists & inhibitors
Histone Demethylases metabolism
Histones genetics
Histones metabolism
Humans
Hydroxamic Acids pharmacology
Hydroxyurea pharmacology
Molecular Sequence Annotation
Piperazines pharmacology
RNA, Small Interfering genetics
RNA, Small Interfering metabolism
Tranylcypromine pharmacology
Vorinostat
alpha-Globins antagonists & inhibitors
alpha-Globins metabolism
beta-Thalassemia drug therapy
beta-Thalassemia enzymology
beta-Thalassemia genetics
beta-Thalassemia pathology
Enzyme Inhibitors pharmacology
Erythroid Cells drug effects
Histone Demethylases genetics
Hydroxyquinolines pharmacology
Small Molecule Libraries pharmacology
alpha-Globins genetics

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