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Electrospun Lipid Binding Proteins Composite Nanofibers with Antibacterial Properties.
Electrospun Lipid Binding Proteins Composite Nanofibers with Antibacterial Properties.
- Source :
-
Macromolecular bioscience [Macromol Biosci] 2017 Apr; Vol. 17 (4). Date of Electronic Publication: 2016 Nov 02. - Publication Year :
- 2017
-
Abstract
- Electrospinning is here used for the first time to prepare nanofibers including a host/guest complex in a keratin/poly(ethylene oxide) matrix. The host is a lipid binding protein and the guest is an insoluble bactericidal molecule, irgasan, bound within the protein internal cavity. The obtained nanofibers, characterized by scanning electron microscopy, exhibit excellent antibacterial activity toward Gram positive and negative bacteria, even with a moderate protein/irgasan cargo. Solution NMR studies, employed to provide molecular information on the cargo system, points to a micromolar affinity, compatible with both the electrospinning process and slow guest release. The versatility of the carrier protein, capable of interacting with a variety of druggable hydrophobic molecules, is exploitable for the development of innovative biomedical devices, whose properties can be tuned by the selected guest.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Carbanilides pharmacology
Chickens
Escherichia coli drug effects
Microbial Sensitivity Tests
Nanofibers ultrastructure
Proton Magnetic Resonance Spectroscopy
Sheep
Solutions
Staphylococcus aureus drug effects
Wettability
Anti-Bacterial Agents pharmacology
Carrier Proteins metabolism
Lipids chemistry
Membrane Glycoproteins metabolism
Nanofibers chemistry
Nanotechnology methods
Subjects
Details
- Language :
- English
- ISSN :
- 1616-5195
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Macromolecular bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 27805768
- Full Text :
- https://doi.org/10.1002/mabi.201600300