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Electrospun Lipid Binding Proteins Composite Nanofibers with Antibacterial Properties.

Electrospun Lipid Binding Proteins Composite Nanofibers with Antibacterial Properties.

Authors :
Tomaselli S
Ramirez DO
Carletto RA
Varesano A
Vineis C
Zanzoni S
Molinari H
Ragona L
Source :
Macromolecular bioscience [Macromol Biosci] 2017 Apr; Vol. 17 (4). Date of Electronic Publication: 2016 Nov 02.
Publication Year :
2017

Abstract

Electrospinning is here used for the first time to prepare nanofibers including a host/guest complex in a keratin/poly(ethylene oxide) matrix. The host is a lipid binding protein and the guest is an insoluble bactericidal molecule, irgasan, bound within the protein internal cavity. The obtained nanofibers, characterized by scanning electron microscopy, exhibit excellent antibacterial activity toward Gram positive and negative bacteria, even with a moderate protein/irgasan cargo. Solution NMR studies, employed to provide molecular information on the cargo system, points to a micromolar affinity, compatible with both the electrospinning process and slow guest release. The versatility of the carrier protein, capable of interacting with a variety of druggable hydrophobic molecules, is exploitable for the development of innovative biomedical devices, whose properties can be tuned by the selected guest.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Details

Language :
English
ISSN :
1616-5195
Volume :
17
Issue :
4
Database :
MEDLINE
Journal :
Macromolecular bioscience
Publication Type :
Academic Journal
Accession number :
27805768
Full Text :
https://doi.org/10.1002/mabi.201600300