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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.
- Source :
-
Nature genetics [Nat Genet] 2016 Dec; Vol. 48 (12), pp. 1535-1543. Date of Electronic Publication: 2016 Oct 31. - Publication Year :
- 2016
-
Abstract
- Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.<br />Competing Interests: Statement The authors have no competing interests as defined by Springer Nature, or other interests that might be perceived to influence the results and/or discussion reported in this paper.
- Subjects :
- Genotype
Global Health
Humans
Mycobacterium tuberculosis isolation & purification
Phylogeography
Tuberculosis genetics
DNA, Bacterial analysis
Genomics methods
Mycobacterium tuberculosis classification
Mycobacterium tuberculosis genetics
Polymorphism, Genetic genetics
Tuberculosis microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 48
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 27798628
- Full Text :
- https://doi.org/10.1038/ng.3704