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Mast cell specific immunological biomarkers and metabolic syndrome among middle-aged and older Chinese adults.
- Source :
-
Endocrine journal [Endocr J] 2017 Mar 31; Vol. 64 (3), pp. 245-253. Date of Electronic Publication: 2016 Oct 27. - Publication Year :
- 2017
-
Abstract
- The main aim of this study is to explore whether these mast cell specific immunological biomarkers [immunoglobulin E (IgE), chymase and tryptase] is an independent risk factor of MetS and whether the combined action of these biomarkers increased the associations with MetS. Three mast cell-specific immunological biomarkers were measured using enzyme linked immunosorbent assay (ELISA). One-way analysis of covariance and logistic regression models were used for analyzing the associations between immunological biomarkers with MetS. A total of 340 participants, 82 (24.1%) individuals had diabetes mellitus, 31 (9.1%) had MetS (without diabetes mellitus) and 110 had MetS plus diabetes mellitus. After adjusting by multivariable (age, gender, smoking, and family history for hypertension), compared with no diabetes mellitus or MetS group (reference group), hs-CRP was associated with diabetes mellitus [OR (odds ratio): 2.29 (1.15-4.57, 95% CI (confidence interval), p=0.019] and MetS plus diabetes mellitus [OR: 2.20 (1.05-4.61, 95% CI), p=0.036], IgE was associated with MetS plus diabetes mellitus [OR: 2.38 (1.13-5.02, 95% CI), p=0.023]. After adjusting by multivariable, compared with reference group, most of combined elevated inflammatory or immunological biomarkers were significantly associated with diabetes mellitus or MetS with or without diabetes mellitus. Patients with established diabetes mellitus or MetS had different inflammatory or immunological cytokine profile (such as hs-CRP, IgE, chymase, tryptase), which indicated that there is an alteration in the function of the immune system in diabetes mellitus or MetS patient. But these results are requested to be further demonstrated for large sample population-based cohort study.
- Subjects :
- Aged
Biomarkers blood
Body Mass Index
China epidemiology
Chymases blood
Chymases metabolism
Cross-Sectional Studies
Female
Humans
Hyperlipidemias physiopathology
Hypertension physiopathology
Male
Mass Screening
Mast Cells metabolism
Metabolic Syndrome epidemiology
Metabolic Syndrome etiology
Metabolic Syndrome metabolism
Middle Aged
Obesity physiopathology
Overweight physiopathology
Prediabetic State diagnosis
Prediabetic State etiology
Risk Factors
Tryptases blood
Tryptases metabolism
C-Reactive Protein analysis
Immunoglobulin E analysis
Insulin Resistance
Mast Cells immunology
Metabolic Syndrome immunology
Up-Regulation
Subjects
Details
- Language :
- English
- ISSN :
- 1348-4540
- Volume :
- 64
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Endocrine journal
- Publication Type :
- Academic Journal
- Accession number :
- 27784852
- Full Text :
- https://doi.org/10.1507/endocrj.EJ16-0388