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Coriandrum sativum Suppresses Aβ42-Induced ROS Increases, Glial Cell Proliferation, and ERK Activation.
- Source :
-
The American journal of Chinese medicine [Am J Chin Med] 2016; Vol. 44 (7), pp. 1325-1347. Date of Electronic Publication: 2016 Oct 25. - Publication Year :
- 2016
-
Abstract
- Alzheimer's disease (AD), the most common neurodegenerative disease, has a complex and widespread pathology that is characterized by the accumulation of amyloid [Formula: see text]-peptide (A[Formula: see text]) in the brain and various cellular abnormalities, including increased oxidative damage, an amplified inflammatory response, and altered mitogen-activated protein kinase signaling. Based on the complex etiology of AD, traditional medicinal plants with multiple effective components are alternative treatments for patients with AD. In the present study, we investigated the neuroprotective effects of an ethanol extract of Coriandrum sativum (C. sativum) leaves on A[Formula: see text] cytotoxicity and examined the molecular mechanisms underlying the beneficial effects. Although recent studies have shown the benefits of the inhalation of C. sativum oil in an animal model of AD, the detailed molecular mechanisms by which C. sativum exerts its neuroprotective effects are unclear. Here, we found that treatment with C. sativum extract increased the survival of both A[Formula: see text]-treated mammalian cells and [Formula: see text]42-expressing flies. Moreover, C. sativum extract intake suppressed [Formula: see text]-induced cell death in the larval imaginal disc and brain without affecting A[Formula: see text]42 expression and accumulation. Interestingly, the increases in reactive oxygen species levels and glial cell number in AD model flies were reduced by C. sativum extract intake. Additionally, C. sativum extract inhibited the epidermal growth factor receptor- and A[Formula: see text]-induced phosphorylation of extracellular signal-regulated kinase (ERK). The constitutively active form of ERK abolished the protective function of C. sativum extract against the [Formula: see text]-induced eye defect phenotype in Drosophila. Taken together, these results suggest that C. sativum leaves have antioxidant, anti-inflammatory, and ERK signaling inhibitory properties that are beneficial for patients with AD.
- Subjects :
- Alzheimer Disease metabolism
Amyloid beta-Peptides metabolism
Animals
Brain cytology
Brain metabolism
Cells, Cultured
Disease Models, Animal
Drosophila
Drosophila Proteins metabolism
ErbB Receptors metabolism
MAP Kinase Signaling System drug effects
Peptide Fragments metabolism
Phosphorylation drug effects
Plant Extracts chemistry
Plant Extracts isolation & purification
Plant Leaves chemistry
Receptors, Invertebrate Peptide metabolism
Rutin isolation & purification
Rutin pharmacology
Rutin therapeutic use
Alzheimer Disease drug therapy
Anti-Inflammatory Agents
Antioxidants
Cell Proliferation drug effects
Coriandrum chemistry
Neuroglia cytology
Neuroglia metabolism
Neuroprotective Agents
Phytotherapy
Plant Extracts pharmacology
Plant Extracts therapeutic use
Reactive Oxygen Species metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1793-6853
- Volume :
- 44
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The American journal of Chinese medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27776428
- Full Text :
- https://doi.org/10.1142/S0192415X16500749