Levodopa-induced morphologic changes of prefrontal pyramidal tract-type neurons in a rat model of Parkinson's disease.

Authors :: Nishijima H
Ueno T
Ueno S
Mori F
Miki Y
Tomiyama M
Source :: Neuroscience research [Neurosci Res] 2017 Feb; Vol. 115, pp. 54-58. Date of Electronic Publication: 2016 Oct 20.
Publication Year :: 2017
Abstract: Long-term administration of levodopa for Parkinson's disease is associated with various motor and non-motor complications. We examined the dendritic spine morphology of pyramidal tract-type neurons in the prefrontal cortex in a rat model of Parkinson's disease chronically treated with levodopa. Dendritic spines showed decreased density and increased average volume after dopamine denervation and levodopa treatment. These morphologic alterations suggest that the prefrontal neurons may maladaptively respond to excitatory input, which might be one of the mechanisms underlying various levodopa-induced complications in patients with Parkinson's disease.<br /> (Copyright © 2016 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.)

Subjects :: Animals
Dendritic Spines drug effects
Dendritic Spines pathology
Male
Neurons pathology
Oxidopamine
Parkinson Disease etiology
Parkinson Disease pathology
Prefrontal Cortex pathology
Pyramidal Tracts pathology
Rats, Wistar
Antiparkinson Agents adverse effects
Dopamine Agents adverse effects
Levodopa adverse effects
Neurons drug effects
Parkinson Disease drug therapy
Prefrontal Cortex drug effects
Pyramidal Tracts drug effects

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