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Brucella abortus S19 vaccine protects dairy cattle against natural infection with Brucella melitensis.
- Source :
-
Vaccine [Vaccine] 2016 Nov 21; Vol. 34 (48), pp. 5837-5839. Date of Electronic Publication: 2016 Oct 19. - Publication Year :
- 2016
-
Abstract
- Brucellosis is a zoonotic disease that can cause severe illness in humans and considerable economic loss in the livestock industry. Although small ruminants are the preferential host for Brucella melitensis, this pathogen has emerged as a cause for Brucella outbreaks in cattle. S19 vaccination is implemented in many countries where B. abortus is endemic but its effectiveness against B. melitensis has not been validated. Here we show that vaccine effectiveness in preventing disease transmission between vaccinated and unvaccinated cohorts, as determined by seroconversion, was 87.2% (95% CI 69.5-94.6%). Furthermore, vaccination was associated with a reduced risk for abortion. Together, our data emphasize the role S19 vaccination could play in preventing B. melitensis outbreaks in areas where this pathogen is prevalent in small ruminant populations.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Abortion, Veterinary microbiology
Animals
Antibodies, Bacterial
Brucella Vaccine immunology
Brucella abortus immunology
Brucella melitensis pathogenicity
Brucellosis, Bovine transmission
Cattle
Cross Protection
Female
Pregnancy
Pregnancy Complications, Infectious prevention & control
Pregnancy Complications, Infectious veterinary
Seroconversion
Vaccination veterinary
Abortion, Veterinary prevention & control
Brucella Vaccine administration & dosage
Brucella melitensis immunology
Brucellosis, Bovine prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 34
- Issue :
- 48
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 27771184
- Full Text :
- https://doi.org/10.1016/j.vaccine.2016.10.011