Back to Search
Start Over
Final oocyte maturation with two different GnRH agonists in antagonist co-treated cycles at risk of ovarian hyperstimulation syndrome.
- Source :
-
Reproductive biomedicine online [Reprod Biomed Online] 2017 Jan; Vol. 34 (1), pp. 5-10. Date of Electronic Publication: 2016 Oct 17. - Publication Year :
- 2017
-
Abstract
- Triptorelin 0.2 mg and leuprolide 1 mg subcutaneous injections for triggering final follicular maturation were compared in patients with a high risk for ovarian hyperstimulation syndrome (OHSS). Infertile patients treated with GnRH antagonist protocol between January 2014 and March 2016 were recruited. Patients with high serum oestradiol levels on HCG day (>3000 pg/ml) indicating a risk of OHSS consisted of the study groups (A and B). Patients with serum oestradiol levels less than 3000 pg/ml consisted of the control group (C). A single injection of 0.2 mg triptorelin, 1 mg leuprolide and 10000 IU HCG were administered for final oocyte triggering in groups A (n = 63), B (n = 74) and C (n = 131), respectively. Demographic parameters were comparable between the groups. No cases of severe or moderate OHSS occurred in any group. The clinical pregnancy rates were 31.7%, 37.8% and 32.8% in groups A, B and C, respectively. Both injections had comparable efficacy in clinical outcome and OHSS risk. Regardless of preferred drug, GnRH agonist trigger for final oocyte maturation seems to be safe for patients with high OHSS risk, and can be safely used in fresh embryo transfer cycles.<br /> (Copyright © 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Estradiol blood
Female
Hormone Antagonists therapeutic use
Humans
Infertility, Female therapy
Infertility, Male therapy
Leuprolide administration & dosage
Male
Oocytes drug effects
Oogenesis
Ovulation Induction
Pregnancy
Pregnancy Rate
Retrospective Studies
Risk
Sperm Injections, Intracytoplasmic
Triptorelin Pamoate administration & dosage
Young Adult
Gonadotropin-Releasing Hormone agonists
Gonadotropin-Releasing Hormone antagonists & inhibitors
Oocytes cytology
Ovarian Hyperstimulation Syndrome drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1472-6491
- Volume :
- 34
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Reproductive biomedicine online
- Publication Type :
- Academic Journal
- Accession number :
- 27771155
- Full Text :
- https://doi.org/10.1016/j.rbmo.2016.10.004