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Ischemia-modified albumin as a predictor of the severity of acute appendicitis.
- Source :
-
The American journal of emergency medicine [Am J Emerg Med] 2017 Jan; Vol. 35 (1), pp. 92-95. Date of Electronic Publication: 2016 Oct 07. - Publication Year :
- 2017
-
Abstract
- Background: The early prediction of gangrenous/perforated appendicitis is of great importance for the surgical planning, further treatments, and predicting the course of disease. Ischemia-modified albumin (IMA) was previously reported as a biomarker of various ischemia-based diseases. Our aim is to determine the predictive value of serum IMA in the severity of acute appendicitis.<br />Methods: Sixty-two patients who underwent urgent appendectomy were included in the study. Plasma level of IMA was measured after diagnosis and before treatment. All patients were classified as noncomplicated (acute) appendicitis and complicated (gangrenous/perforated) appendicitis according to histopathological findings, and comparisons were made between the groups.<br />Results: The data of 62 patients with a mean age of 30.1 years were statistically evaluated. The pathological diagnoses were acute appendicitis in 33 (53.2%), and gangrenous/perforated appendicitis in 29 (46.8%) patients. There were significant differences in computed tomography (CT) findings (P = .031) and IMA (P = .012) levels between the groups. A strong positive correlation between IMA levels and CT findings was also found (Spearman ρ = +0.688, P = .003).<br />Conclusions: The IMA can be considered as a novel and useful marker to distinguish gangrenous/perforated appendicitis from noncomplicated appendicitis. The correlation of IMA with CT findings also enhances the predictive value of IMA.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Appendectomy
Appendicitis diagnostic imaging
Appendicitis pathology
Appendicitis surgery
Biomarkers blood
Cecal Diseases blood
Cecal Diseases diagnostic imaging
Cecal Diseases pathology
Cecal Diseases surgery
Female
Gangrene
Humans
Intestinal Perforation diagnostic imaging
Intestinal Perforation pathology
Intestinal Perforation surgery
Laparoscopy
Male
Middle Aged
Serum Albumin
Serum Albumin, Human
Severity of Illness Index
Tomography, X-Ray Computed
Young Adult
Appendicitis blood
Appendix pathology
Intestinal Perforation blood
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8171
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The American journal of emergency medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27769665
- Full Text :
- https://doi.org/10.1016/j.ajem.2016.10.010