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Novel mitochondria-targeted, nitrogen mustard-based DNA alkylation agents with near infrared fluorescence emission.

Authors :
Chen X
Chen H
Lu C
Yang C
Yu X
Li K
Xie Y
Source :
Talanta [Talanta] 2016 Dec 01; Vol. 161, pp. 888-893. Date of Electronic Publication: 2016 Aug 16.
Publication Year :
2016

Abstract

In this report, the design of two novel nitrogen mustard-based DNA cross-linking agents with fluorophores incorporated into the structure (TN-A and TN-B) is disclosed. The results indicate that TN-A and TN-B can serve directly as both reporting and imaging agents for flow cytometry and gel electrophoresis without the necessity of another fluorescent tagging agents. TN-A and TN-B both selectively locate in the mitochondria and exhibit good antitumor activity. Notably, TN-A is the first DNA crosslinking agent with near infrared fluorescence emission properties.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1873-3573
Volume :
161
Database :
MEDLINE
Journal :
Talanta
Publication Type :
Academic Journal
Accession number :
27769499
Full Text :
https://doi.org/10.1016/j.talanta.2016.08.051