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Novel mitochondria-targeted, nitrogen mustard-based DNA alkylation agents with near infrared fluorescence emission.
- Source :
-
Talanta [Talanta] 2016 Dec 01; Vol. 161, pp. 888-893. Date of Electronic Publication: 2016 Aug 16. - Publication Year :
- 2016
-
Abstract
- In this report, the design of two novel nitrogen mustard-based DNA cross-linking agents with fluorophores incorporated into the structure (TN-A and TN-B) is disclosed. The results indicate that TN-A and TN-B can serve directly as both reporting and imaging agents for flow cytometry and gel electrophoresis without the necessity of another fluorescent tagging agents. TN-A and TN-B both selectively locate in the mitochondria and exhibit good antitumor activity. Notably, TN-A is the first DNA crosslinking agent with near infrared fluorescence emission properties.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Alkylating Agents chemical synthesis
Apoptosis drug effects
Cell Survival drug effects
Fluorescence
Fluorescent Dyes chemical synthesis
HeLa Cells
Humans
Nitrogen Mustard Compounds chemical synthesis
Alkylating Agents pharmacology
Fluorescent Dyes pharmacology
Mitochondria metabolism
Nitrogen Mustard Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3573
- Volume :
- 161
- Database :
- MEDLINE
- Journal :
- Talanta
- Publication Type :
- Academic Journal
- Accession number :
- 27769499
- Full Text :
- https://doi.org/10.1016/j.talanta.2016.08.051