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Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation.
- Source :
-
JACC. Basic to translational science [JACC Basic Transl Sci] 2016 Apr 25; Vol. 1 (3), pp. 131-142.. Date of Electronic Publication: 2016 Apr 25 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc. Cross-linking potentiated the inhibition of human plaque- and collagen-induced platelet aggregation by GPVI-Fc under static and flow conditions without increasing bleeding time in vitro. Cross-linking with anti-human-Fc Fab2 was even superior to anti-human-Fc immunoglobulin G (IgG). Advanced optical imaging revealed a continuous sheath-like coverage of collagen fibers by cross-linked GPVI-Fc complexes. Cross-linking of GPVI into oligomeric complexes provides a new, highly effective, and probably safe antithrombotic treatment as it suppresses platelet GPVI-plaque interaction selectively at the site of acute atherothrombosis.
Details
- Language :
- English
- ISSN :
- 2452-302X
- Volume :
- 1
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- JACC. Basic to translational science
- Publication Type :
- Academic Journal
- Accession number :
- 27766315
- Full Text :
- https://doi.org/10.1016/j.jacbts.2016.03.008