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RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.
- Source :
-
Oncotarget [Oncotarget] 2016 Oct 25; Vol. 7 (43), pp. 70475-70480. - Publication Year :
- 2016
-
Abstract
- RTEL1 (regulator of telomere elongation helicase 1; OMIM 608833) gene polymorphisms were linked to lung cancer (LC) susceptibility in a cancer genome-wide association study (GWAS) Here, we assessed whether seven previously reported RTEL1 polymorphisms influenced LC risk in Han Chinese population. All study samples (554 LC cases and 696 cancer-free controls) were collected from the Affiliated Hospital of Xizang Minzu University in China. We assessed associations between SNPs and LC risk using various several genetic models (codominant, dominant, recessive, overdominant, and additive). Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model). Haplotype analysis suggested that ''CTC'' was associated with a 0.8-fold decrease in LC risk (OR = 0.80, 95% CI, 0.63-1.00; Pearson's p = 0.05). These findings suggest a potential association between RTEL1 polymorphisms and LC risk in a Chinese Han population.
- Subjects :
- Adult
Aged
Aged, 80 and over
Asian People genetics
China
Female
Gene Frequency
Genetic Predisposition to Disease ethnology
Genome-Wide Association Study
Genotype
Haplotypes
Humans
Lung Neoplasms ethnology
Male
Middle Aged
Odds Ratio
Risk Factors
Young Adult
DNA Helicases genetics
Genetic Predisposition to Disease genetics
Lung Neoplasms genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1949-2553
- Volume :
- 7
- Issue :
- 43
- Database :
- MEDLINE
- Journal :
- Oncotarget
- Publication Type :
- Academic Journal
- Accession number :
- 27765928
- Full Text :
- https://doi.org/10.18632/oncotarget.12297