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Oral Toxicity of 2,4-Dinitroanisole in Rats.
- Source :
-
International journal of toxicology [Int J Toxicol] 2016 Nov; Vol. 35 (6), pp. 692-711. Date of Electronic Publication: 2016 Oct 07. - Publication Year :
- 2016
-
Abstract
- Subacute and subchronic studies were conducted to assess the toxicity of 2,4-dinitroanisole (DNAN) and to provide information important for protecting the health of military and civilian personnel. In the subchronic study, male and female Sprague-Dawley rats were dosed with DNAN via oral gavage at 0, 1.25, 5, 20, and 80 mg/kg/d. Likely owing to its conversion to 2,4-dinitrophenol, an inhibitor of energy homeostasis, DNAN caused an apparent increase in metabolism, leading to reduced feed efficiency ratios and body mass gains in males. Anemia, splenic enlargement, hemosiderosis, and extramedullary hematopoiesis indicated blood as a target organ, with females more sensitive than males. The DNAN was a testicular toxicant, causing decreased mass of testes and epididymides, as well as degeneration and atrophy of testicular seminiferous tubules and epididymal aspermia. Stereotypical behavior in males, gait irregularities, and cerebellar lesions indicated that DNAN is neurotoxic. Splenic enlargement, anemia, testicular toxicity, and neurotoxicity occurred only at or near lethal doses in the subchronic study.<br /> (© The Author(s) 2016.)
- Subjects :
- Administration, Oral
Animals
Blood Cell Count
Body Weight drug effects
Brain drug effects
Brain pathology
Epididymis drug effects
Epididymis pathology
Female
Hematopoiesis drug effects
Hemosiderosis chemically induced
Male
Neurotoxicity Syndromes
Organ Size drug effects
Rats
Rats, Sprague-Dawley
Sperm Count
Sperm Motility drug effects
Spinal Cord drug effects
Spleen drug effects
Spleen pathology
Testis drug effects
Testis pathology
Toxicity Tests, Subacute
Toxicity Tests, Subchronic
Anisoles toxicity
Explosive Agents toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1092-874X
- Volume :
- 35
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 27765881
- Full Text :
- https://doi.org/10.1177/1091581816670321