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Brain 18 F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2017 Mar; Vol. 58 (3), pp. 492-498. Date of Electronic Publication: 2016 Oct 20. - Publication Year :
- 2017
-
Abstract
- The aim of this study was to characterize brain metabolic abnormalities in patients with macrophagic myofascitis (MMF) and the relationship with cognitive dysfunction through the use of PET with <superscript>18</superscript> F-FDG. Methods: <superscript>18</superscript> F-FDG PET brain imaging and a comprehensive battery of neuropsychological tests were performed in 100 consecutive MMF patients (age [mean ± SD], 45.9 ± 12 y; 74% women). Images were analyzed with statistical parametric mapping (SPM12). Through the use of analysis of covariance, all <superscript>18</superscript> F-FDG PET brain images of MMF patients were compared with those of a reference population of 44 healthy subjects similar in age (45.4 ± 16 y; P = 0.87) and sex (73% women; P = 0.88). The neuropsychological assessment identified 4 categories of patients: those with no significant cognitive impairment ( n = 42), those with frontal subcortical (FSC) dysfunction ( n = 29), those with Papez circuit dysfunction ( n = 22), and those with callosal disconnection ( n = 7). Results: In comparison with healthy subjects, the whole population of patients with MMF exhibited a spatial pattern of cerebral glucose hypometabolism ( P < 0.001) involving the occipital lobes, temporal lobes, limbic system, cerebellum, and frontoparietal cortices, as shown by analysis of covariance. The subgroup of patients with FSC dysfunction exhibited a larger extent of involved areas (35,223 voxels vs. 13,680 voxels in the subgroup with Papez circuit dysfunction and 5,453 voxels in patients without cognitive impairment). Nonsignificant results were obtained for the last subgroup because of its small population size. Conclusion: Our study identified a peculiar spatial pattern of cerebral glucose hypometabolism that was most marked in MMF patients with FSC dysfunction. Further studies are needed to determine whether this pattern could represent a diagnostic biomarker of MMF in patients with chronic fatigue syndrome and cognitive dysfunction.<br /> (© 2017 by the Society of Nuclear Medicine and Molecular Imaging.)
- Subjects :
- Adolescent
Adult
Aged
Brain diagnostic imaging
Brain Diseases, Metabolic diagnostic imaging
Chronic Disease
Cognition Disorders diagnostic imaging
Fasciitis diagnostic imaging
Female
Fluorodeoxyglucose F18 pharmacokinetics
Humans
Male
Middle Aged
Myositis diagnostic imaging
Radiopharmaceuticals pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
Young Adult
Brain metabolism
Brain Diseases, Metabolic metabolism
Cognition Disorders metabolism
Fasciitis metabolism
Glucose metabolism
Myositis metabolism
Positron-Emission Tomography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1535-5667
- Volume :
- 58
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27765861
- Full Text :
- https://doi.org/10.2967/jnumed.114.151878