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Whole Genome Sequence of Two Wild-Derived Mus musculus domesticus Inbred Strains, LEWES/EiJ and ZALENDE/EiJ, with Different Diploid Numbers.
- Source :
-
G3 (Bethesda, Md.) [G3 (Bethesda)] 2016 Dec 07; Vol. 6 (12), pp. 4211-4216. Date of Electronic Publication: 2016 Dec 07. - Publication Year :
- 2016
-
Abstract
- Wild-derived mouse inbred strains are becoming increasingly popular for complex traits analysis, evolutionary studies, and systems genetics. Here, we report the whole-genome sequencing of two wild-derived mouse inbred strains, LEWES/EiJ and ZALENDE/EiJ, of Mus musculus domesticus origin. These two inbred strains were selected based on their geographic origin, karyotype, and use in ongoing research. We generated 14× and 18× coverage sequence, respectively, and discovered over 1.1 million novel variants, most of which are private to one of these strains. This report expands the number of wild-derived inbred genomes in the Mus genus from six to eight. The sequence variation can be accessed via an online query tool; variant calls (VCF format) and alignments (BAM format) are available for download from a dedicated ftp site. Finally, the sequencing data have also been stored in a lossless, compressed, and indexed format using the multi-string Burrows-Wheeler transform. All data can be used without restriction.<br /> (Copyright © 2016 Morgan et al.)
Details
- Language :
- English
- ISSN :
- 2160-1836
- Volume :
- 6
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- G3 (Bethesda, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 27765810
- Full Text :
- https://doi.org/10.1534/g3.116.034751