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Targeted Co-delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer.
- Source :
-
Small (Weinheim an der Bergstrasse, Germany) [Small] 2017 Jan; Vol. 13 (2). Date of Electronic Publication: 2016 Oct 20. - Publication Year :
- 2017
-
Abstract
- A new type of tumor-targeted nanovehicle peptide-conjugated PSPG (PSPGP) is successfully synthesized for co-delivery of paclitaxel (PTX) and TR3 small interfering RNA (siRNA). In vitro and in vivo investigations demonstrate that the redox-responsive PSPGP exhibit enhanced endosomal escape and intracellular degradation, which facilitate PTX and TR3 siRNA release, effectively improving the antitumor efficacy.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Cell Line, Tumor
Humans
Injections, Intravenous
Mice
Paclitaxel pharmacology
Particle Size
Proton Magnetic Resonance Spectroscopy
Static Electricity
Temperature
Xenograft Model Antitumor Assays
Dendrimers chemistry
Nuclear Receptor Subfamily 4, Group A, Member 1 metabolism
Paclitaxel administration & dosage
Paclitaxel therapeutic use
Pancreatic Neoplasms drug therapy
Peptides chemistry
RNA, Small Interfering administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1613-6829
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Small (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 27762495
- Full Text :
- https://doi.org/10.1002/smll.201602697