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Zoanthamine-Type Alkaloids from the Zoanthid Zoanthus kuroshio Collected in Taiwan and Their Effects on Inflammation.

Authors :
Hsu YM
Chang FR
Lo IW
Lai KH
El-Shazly M
Wu TY
Du YC
Hwang TL
Cheng YB
Wu YC
Source :
Journal of natural products [J Nat Prod] 2016 Oct 28; Vol. 79 (10), pp. 2674-2680. Date of Electronic Publication: 2016 Oct 19.
Publication Year :
2016

Abstract

Zoanthus kuroshio is a colorful zoanthid with a fluorescent pink oral disc and brown tentacles, which dominates certain parts of the Taiwanese and Japanese coasts. This sea anemone is a rich source of biologically active alkaloids. In the current investigation, two novel halogenated zoanthamines [5α-iodozoanthenamine (1) and 11β-chloro-11-deoxykuroshine A (2)], along with four new zoanthamines [18-epi-kuroshine A (3), 7α-hydroxykuroshine E (4), 5α-methoxykuroshine E (5), and 18-epi-kuroshine E (6)], and six known compounds were isolated from Z. kuroshio. Compounds 1 and 2 are the first examples of halogenated zoanthamine-type alkaloids isolated from nature. Compounds 3 and 6 are the first zoanthamine stereoisomers with a cis-junction of the A/B rings. All isolated compounds were evaluated for their anti-inflammatory activities by measuring their effects on superoxide anion generation and elastase release by human neutrophils in response to fMLP.

Details

Language :
English
ISSN :
1520-6025
Volume :
79
Issue :
10
Database :
MEDLINE
Journal :
Journal of natural products
Publication Type :
Academic Journal
Accession number :
27759384
Full Text :
https://doi.org/10.1021/acs.jnatprod.6b00625